NL Journal of Medical and Pharmaceutical Sciences
(ISSN: 3108-0502)

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Metachronous Double Primary Malignancy: Triple-Negative Carcinoma Breast Followed by Carcinosarcoma Uterus – A Rare Case Report

Author(s) : Pramod Kumar Singh, Archana Singh* , Ayushi Singh.
DOI : 10.71168/NMP.02.01.121

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Abstract

Double primary malignancies are uncommon occurrences, and their coexistence poses diagnostic and therapeutic challenges. While carcinoma breast and endometrial malignancy association is often linked to hormonal therapy (notably tamoxifen), the development of endometrial carcinoma in the absence of hormonal treatment is exceedingly rare. We report a case of a 32-year-old female with carcinoma breast (triple-negative subtype) successfully treated with multimodality therapy, who after a disease-free interval of seven years, developed a second primary malignancy—carcinosarcoma of the uterus. This case highlights the need for vigilance in long-term cancer survivors, even in the absence of endocrine therapy. Keywords: Metachronous double primary malignancy, Triple-negative breast cancer, Uterine carcinosarcoma, Second primary malignancy, Long-term cancer survivor.

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